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After 6 weeks, alpha-lipoic acid reduced diabetic nerve pain intensity (on a 0–10 scale) from 5.32 at baseline to 3.53, while pregabalin reduced it to 2.72
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These four octadecanoids activated both TRPV1 and TRPA1, resulting in postburn mechanical and thermal allodynia (i.e., pain from a typically nonpainful stimulus), which could be reversed by treatment with CYP inhibitors
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