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AOD‑9604, by contrast, is not FDA‑approved as an obesity medication, and while safety data are reassuring, its use for weight loss remains off‑label with mixed evidence for effectiveness

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Oxidative stress biomarkers—such as malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), and glutathione-to-oxidized glutathione ratio (GSH/GSSG)—can provide context for personalizing sleep support strategies