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After back-transformation from log (cortisol + 1 nmol/L) to raw cortisol, model-predicted mean waking value was 12.9 nmol/L in all three specifications, predicted mean peak was 18.7 nmol/L in two of the three models and 18.4 nmol/L in the quadratic spline model, and predicted mean nadir was 2.1 nmol/L in the linear spline model and 2.3 nmol/L in the other two models

100-ml (1000mcg/ml)

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Established CD38 increase and NAMPT/sirtuin decline as the primary age-related NAD+ consumption imbalance