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Under unfolded protein stress conditions, GRP78 binds to unfolded or misfolded proteins and subsequently activates downstream ER stress sensors, including IRE1, PERK, and ATF6, to trigger a response to unfolded proteins (Yoboue et al., 2017) , (Wei et al., 2012)
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It is thought that, initially, the immune cells may be there with good intentions — to clean up dead and diseased thyroid cells — but at some point, they begin to attack healthy thyroid tissues as well
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