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These data, along with the positive associations observed between SBP and both urinary hyaluronidase activity and AQP2/creatinine ratio, support the existence of a close relationship between renal hyaluronidases and vasopressinergic system activation, which could affect water metabolism under both normotensive and sustained hypertensive conditions

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To explore its therapeutic potential, an AAV was designed to express the primary transcript for miRNA-335-5p under the control of the hSyn promoter (AAV9-pri-miR-335), with the aim of upregulating miR-335-5p expression