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5-amino-1MQ, an analogue from our initial series of NNMT inhibitors with low IC 50 value (IC 50 = ~1 µM;[17]), and high cell membrane permeability (Table 2), produced the greatest reduction of intracellular 1-MNA levels at a concentration of 10 µM among tested inhibitors (Figure 2D)
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Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: further development of a rodent model of autism
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