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Intracellular ROS accumulation increases unstable iron and lipid peroxidation deposition through AMPK/NCOA4-mediated ferritinophagy, ultimately leading to ferroptosis and dysfunction in rat BMSCs
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However, these drugs also have certain limitations and side effects in clinical application, such as increased risk of bleeding and adverse gastrointestinal reactions (Sostres et al., 2019)
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