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The MS data obtained for spot B (MW ~35, pI ~8.1), matched two different protein identities: an immunoglobulin fragment and a C-terminal albumin fragment, suggesting that the spot contains a mixture of both protein fragments
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As metabolism constitutes a primary driver of tumor growth, understanding metabolic reprogramming in CRC cells and the TME can identify direct therapeutic targets for disease prevention and treatment, while precision interventions based on this knowledge can augment the efficacy of other therapeutic modalities
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