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Anti-inflammatory mechanisms include modulation of inflammatory cytokines and reduction of nuclear factor-kappa B (NF-κB) activity, a key inflammatory pathway

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The relevant coding sequence of Strain 13324 is: The translation of this nucleotide sequence is as follows: Strain 13324 (huFC(IgG1)S196C): The cDNA clones constructed as described in Example 1 hereinabove: Strain 13300 (huFc(IgG1)Q143C), Strain 13322 (huFc(IgG1)L139C), Strain 13323 (huFc(IgG1)S145C) and Strain 13324 (huFc(IgG1)S196C) were transformed in E