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demonstrated that a single low-dose immunization with any of the three developed LNP-based herpes simplex virus type 1 glycoprotein D (gDE7) mRNA vaccines (self-amplifying mRNA, unmodified mRNA, and nucleoside-modified non-replicating mRNA vaccines) resulted in the activation of E7-specific CD8 + T cells, generated memory T cell responses to prevent tumor relapses, and destroyed cervical tumors (Ramos da Silva et al., 2023a)