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Generally, NNMT activity or expression is significantly elevated in cancers, such as brain [68], lung [69], liver [70], kidney [71, 72], bladder [73], stomach [74, 75], pancreas [76], colon [77], and oral [78, 79] cancer but cancer cells usually have a significantly higher anaerobic metabolism rate than normal cells

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→ Stacking considerations: Can be combined with lifestyle interventions (calorie deficit, exercise) and, in some protocols, with other peptides such as CJC-1295/Ipamorelin for enhanced metabolic impact