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Clinical effectiveness and prospects of methylene blue: a systematic review

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In human renal proximal tubular cells, OAT 1, OAT2 and OAT 3 are located in the basolateral membrane and, driven by the exchange of dicarboxylates, mediate the movement of organic anions from the blood into tubular cells, while OAT4 and OAT10 are located in the apical membrane and facilitate the secretion of organic ions from tubular cells into the urine [8]