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Liraglutide is sold as Saxenda and works through the same GLP-1 receptor agonist mechanism as semaglutide and tirzepatide, mimicking GLP-1 to regulate appetite and blood sugar rather than acting on the GIP pathway that tirzepatide also targets

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This leads to damage to tissue cells, including vascular ECs (Incalza et al., 2018), adipocytes (Furukawa et al., 2004), and pancreatic β-cells (Gerber and Rutter, 2017)