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This alarming trend underscores the urgent need for awareness and proactive measures to address B12 deficiency, especially among older adults who may experience symptoms like fatigue, weakness, and mood disturbances

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4.1.4 Biodegradability and biocompatibility The choice of biomaterial is a crucial step in nanoparticle development, as the properties of biomaterials reflect not only physical characteristics but also their biodegradation and biocompatibility profiles, in which the suitable biomaterials should exhibit non-immunogenicity (Nunes et al., 2022