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5.2 Therapeutic efficacy in animal models 5.2.1 Neurodegenerative disorders Several compounds have demonstrated significant therapeutic potential in animal models of neurodegenerative diseases, such as AD and PD (Carrera and Cacabelos, 2019)

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In addition, chemical modification of FDA approved NSAIDs, by pharmacophore modification, aimed at reducing their toxic effects and improving their bioavailability without compromising the therapeutic effects is strongly advocated