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Oxidative stress leads to endothelial dysfunction, which can cause cardio-cerebrovascular complications and exacerbate upper airway obstruction, which creates a vicious cycle

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With the higher levels of salivary AMPs, the microbial load decreases and the oral epithelium finally matures, having a greater turnover and a reduced expression of microbial recognition receptors, including TLR2 and TLR4, and lower expression of antimicrobial defensins

but internal and external factors adversely affect the amount of Glutathione your body produces