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7 Underlying mechanisms include obesity-related comorbidities (T2DM, cardiovascular and renal diseases), immune system impairments facilitating a systemic diffusion of infection, increased type 2 inflammation with effects on the lung parenchyma, raised IL-6 levels, and abnormal secretion of adipokines and cytokines inducing low-grade inflammation

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The gut microbiome composition is altered in long-standing type 1 diabetes and associates with glycemic control and disease-related complications