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“You read the studies, you look at the lab tests, and you see all the positive effects,” said Thomas, who believes that the risks are “rare and not serious.” However, neuroscientist Armelle Rancillac at the French Institute of Health and Medical Research (INSERM) said that knowledge on how to use these peptides remains limited, because they “have often not been tested on humans.” Earlier this year, INSERM said that “no large-scale, randomized controlled clinical trial has confirmed” the promised benefits of peptides, warning that some pose “very real health risks.” “We are not giving research enough time to prove its worth,” Rancillac said, adding that “scientifically worthless” accounts of self-experimentation were being given too much credence

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New England Journal of Medicine (2025) 3