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Systemic is defined as including a minimum of two distinct organ systems and may include: Urticaria Flushing Pruritus Angioedema Nasal congestion Nasal pruritus Wheezing Throat swelling Hoarseness Headache Hypotensive syncope Tachycardia Abdominal cramping Diarrhea Biochemical markers: Consensus-2 also includes a 20% plus 2 ng/ml increase in serum tryptase level from the individual’s baseline, but extends to additional biochemical markers as well

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Also, miR-26a inhibits tumor growth, metastasis and angiogenesis of HCC via targeting HGF-induced c-Met signaling pathways and FBXO11, ST3GAL5 signaling pathways (Yang et al., 2014