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During hepatic injury, hepatocytes, neutrophils, and macrophages generate high levels of reactive oxygen species (O 2 − , OH and hydrogen peroxide [H 2 O 2 ]), which are thought to increase oxidative stress, cause direct cytotoxicity, or act as intracellular signalling mediators ( Sophora flavescens (Kushen) has been used for a long time in clinical practice of Mongolian medicine and has good clinical effect ( S