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106,107,108,109,110,111 Similarly, morphological atrophy and functional asthenia of astrocytes contribute to the pathophysiology of various neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD)

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The discrepancy could be due to the difference in cell models and the high rapamycin concentration (100 nM) used in that study which may have induced cell stress 24