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NAC has stronger clinical evidence for liver support and is used in NHS hospitals for paracetamol overdose, whereas direct glutathione supplements have variable absorption and limited evidence for fatty liver disease
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Preliminary studies have shown that targeting GLO1 by small molecule inhibitors such as S-p-bromobenzylglutathione cyclopentyl diester (BBGC) significantly inhibits the growth and induces apoptosis of leukemia and other tumor cells, while reversing the resistance of cancer cells to chemotherapeutic drugs (103, 144, 152–154)
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