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about 40 mM in whole blood) was shown to be able to block any oxidation of thiols to disulfides and to represent the reference procedure to measure the intracellular GSH and GSSG concentration in a reliable way

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Given the possibility that cimetidine may benefit a subset of patients without significant AEs in the context of a small total sample exposed to the drug (n=40, including the RCT), the lack of long-term follow-up data on sufficient numbers of patients, and its potential to interact with other drugs, oral cimetidine was designated as an Option