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SAM provides propylamine for the biosynthesis of polyamine and donates a methyl group for the methylation of histone [47]

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A number of epitopes from structural and nonstructural viral proteins conserved across a curated subset of β-coronaviruses (human and animal [100]) have been combined into an antigen for delivery in an adeno-associated viral vector that has shown pan-SARS-CoV-2 variant protection in mice [151]