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Despite the interesting results of this study and the advantage of being randomized and double-blinded, it has some limitations, including the enrollment of patients with high levels of oxidative stress (e.g., smokers, diabetics, elderly), the presence of compounds other than antioxidants in the supplement used and the heterogeneity of participants as far as tinnitus duration and severity, hearing loss, family history and age of tinnitus onset are concerned, shown to influence the response to treatment [71,72]

limiting factor of the coupled reactions.