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This is the mechanistic reason researchers study it separately from native IGF-1: with less protein-binding interference, the analog remains bioavailable roughly 3x longer, giving it an extended half-life of approximately 20–30 hours compared to native IGF-1’s 12–15 hours

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For example, several studies indicated a potential protective effect of 25-(OH) vitamin D (Vit D) on sleep [15,16,17,18]