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Recently, a large number of articles have found that agents including edaravone and epigallocatechin-3-gallate (EGCG) prevented the development of cisplatin-related brain inflammation and oxidative damage by up-regulating the gene expression level of the Nrf2/HO-1 pathway and preventing the cisplatin-induced NF-κB activation (Jangra et al., 2016

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Nausea occurs in roughly 8-12% of subjects, while fatigue affects 15-20%