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10.1177/09636897231163217 211 NajjarF.OwleyT.MosconiM

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Key findings include: Upregulation of VEGFR2 expression and internalization in endothelial cells Activation of the VEGFR2-Akt-eNOS signaling cascade Enhanced endothelial cell proliferation and tube formation Improved collateral circulation in ischemic injury models The peptide’s pro-angiogenic effects appear particularly relevant in healing scenarios where blood supply restoration is critical for tissue recovery