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These include: The severity of B12 deficiency The presence of underlying health conditions Genetic variations affecting B12 metabolism The duration of supplementation Knowing these factors helps tailor the dose to meet individual needs, ensuring the best results

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In MET -amplified cancers like NSCLC, MET can form heterodimeric complexes with these receptors 57,119,120,121,122,123 , which often become highly phosphorylated in a MET-dependent manner and contribute to sustained oncogenic signaling 124