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Antibodies such as RVS10 and OX26, which bind to epitopes on the extracellular domain of TfR1 distal to the Tf-binding site, have been engineered to circumvent this limitation [269,270,271]
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Acknowledgements The authors are supported by National Institutes of Health (NIH) grants R33HL154252, R01EY035853 and U54CA268083 (P.C.S.), and VA RSF Banks.025 (W.A.B.)
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