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Zinc supplementation of the organoids reversed the effects on gene expression and demonstrates that zinc-dependent HDACs obtain zinc from ZIP14-mediated import and that intestinal integrity is at least partially controlled by epigenetic modifications

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Fibroblasts and endothelial cells also significantly influence pigmentation, with fibroblasts affecting melanocyte proliferation and pigmentation through MAPK and WNT/β-catenin pathways, while endothelial cells stimulate and inhibit pigmentation

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