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CoQ10 supplementation, when added to pregabalin, significantly reduced pain and mitochondrial oxidative stress in FM patients, with improved anxiety and brain activity profiles in a small RCT ( Oxygen-ozone (O₂O₃) therapy, an intervention that activates NRF2, increases SOD, catalase, and HO-1, while suppressing pro-inflammatory cytokines (IL-6, TNF-α, IL-1β) ( − , H₂O₂), protecting mitochondria, and enhancing ATP production ( Molecular hydrogen (H₂) is emerging as a potential therapy targeting oxidative stress, mitochondrial dysfunction, and inflammation
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