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Vitamin B6: Though some research suggests vitamin B6 could help alleviate some of the emotional symptoms of PMDD, the small amount in this supplement is most likely added to help the body better metabolize the supplemental 5-HTP into serotonin.64 65 Lion’s mane: While research is still emerging, lion’s mane may help support mood and reduce inflammation.66 The amount included here is relatively modest compared to doses used in clinical studies, so it likely plays more of a supporting role in the formula