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LEfSe is known to reduce false positives and can highlight biological consistency across subclasses, while the Kruskal–Wallis test used alone can achieve a lower false-negative rate compared to LEfSe 38

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The short answer is “Until you are satisfied with improvements in communication and the treatment no longer seems to be helping.” Another useful response is, “Consider discontinuing mB12 when stimming becomes more disruptive than language acquisition.” I find it peculiar that parents pose this question at all