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In infections characterized by overwhelming toxicity, dexamethasone sodium phosphate therapy, in conjunction with indicated antibacterial therapy, is effective in reducing mortality

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Pre-clinical findings point to activity across multiple pathways: upregulation of vascular endothelial growth factor (VEGF), modulation of nitric oxide synthesis, interaction with growth hormone receptor signaling, and what researchers describe as a cytoprotective effect on epithelial and endothelial tissue