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These findings are supported by many studies reporting the anti-inflammatory action of cortistatin on macrophages, neutrophils, and microglia in other conditions through mechanisms that involve both sstr and GHSR and the regulation of multiple intracellular signals [15,27,60,61,62,63,64]

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10 Specialist advice or referral should be sought immediately if: 6 The rash is severe, widespread or affecting multiple dermatomes Systemic symptoms are present The patient is severely immunocompromised, e.g