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SLC33A1-mediated glutathione transport regulates ER redox balance and function | Nature Cell Biology
In mouse models of insulin resistance, it significantly inhibits NNMT activity in liver and muscle, reduces NAM methylation, increases intracellular NAD+, activates the SIRT1 pathway, promotes phosphorylation of insulin receptor substrate 1 (IRS‑1), enhances insulin signaling, improves insulin sensitivity, and increases glucose uptake and utilization
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A total of six data points from the duplicates of continuous assays were used to obtain the V/[E] (min −1 ) values, presented as mean ± SEM with error bars